One problem of interpreting research on subconscious processing is the possibility that participants are weakly conscious of the stimuli. Here, we compared the fMRI BOLD response in healthy adults to clearly visible single letters with the response to letters presented in the absence of any behavioural evidence of visibility . No letter catch trials served as a control condition. Forced-choice responses did not differ from chance when letter-to-background contrast was low, whereas they were almost 100% correct when contrast was high. (...) A comparison of fMRI BOLD signals for supraliminal and subliminal letters with the control trials revealed a signal increase in left BA 37 . Comparison of supraliminal with subliminal letters showed a significant increase in the right inferior frontal gyrus . Finally, a comparison of subliminal with supraliminal letters showed increases in the left middle temporal gyrus and the right extrastriate cortex. (shrink)

If stem cell-based therapies are developed, we will likely confront a difficult problem of justice: for biological reasons alone, the new therapies might benefit only a limited range of patients. In fact, they might benefit primarily white Americans, thereby exacerbating long-standing differences in health and health care.

We report on the deliberations of an interdisciplinary group of experts in science, law, and philosophy who convened to discuss novel ethical and policy challenges in stem cell research. In this report we discuss the ethical and policy implications of safety concerns in the transition from basic laboratory research to clinical applications of cell-based therapies derived from stem cells. Although many features of this transition from lab to clinic are common to other therapies, three aspects of stem cell biology pose (...) unique challenges. First, tension regarding the use of human embryos may complicate the scientific development of safe and effective cell lines. Second, because human stem cells were not developed in the laboratory until 1998, few safety questions relating to human applications have been addressed in animal research. Third, preclinical and clinical testing of biologic agents, particularly those as inherently complex as mammalian cells, present formidable challenges, such as the need to develop suitable standardized assays and the difficulty of selecting appropriate patient populations for early phase trials. We recommend that scientists, policy makers, and the public discuss these issues responsibly, and further, that a national advisory committee to oversee human trials of cell therapies be established. **NB we did not reccommend a NAC, we think it might be appropriate**. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Bibliography of Resources by and about André E. Hellegers*Compiled by Doris Mueller Goldstein (bio)This bibliography is derived from the holdings of the National Reference Center for Bioethics Literature and the BIOETHICSLINE© database (both of which are at the Kennedy Institute of Ethics and supported by the National Library of Medicine); the archives of Lauinger Library, Georgetown University; the Medline databases of the National Library of Medicine; the WorldCat database (...) of OCLC, Dublin, Ohio, and selected Internet sites.Primarily comprised of writings by Dr. Hellegers, the list also includes interviews and media programs in which he participated, as well as writings about him that were written following his death. The arrangement within each section is by date. The 231 authored pieces reflect the transition from Dr. Hellegers’s early career as a researcher in fetal physiology at Johns Hopkins Medical School, where he published his first research report at the age of 29, to the early years of the Kennedy Institute, where he produced so many provocative columns on bioethical issues that influenced the growth of the field.Due to the diversity of sources and the 40-year time span covered, there are some variations in bibliographic style. Time and availability constraints precluded verifying all of the citations with the original documents. Any additions or corrections should be submitted to the compiler.Works Authored by André E. HellegersNo Date Ethical Issues in Sterilization of the Retarded. Unpublished paper.1956Vitamin B12 Serum Level and Pregnancy. American Journal of Clinical Nutrition 4: 440+, 1956. [With Bacon F. Chow and Kunio Okuda] [End Page 89]1957Vitamin B12 Absorption in Pregnancy and in the Newborn. American Journal of Clinical Nutrition 5: 327+, 1957. [With Bacon F. Chow, Robert E. L. Nesbitt, Kunio Okuda, and David W. Smith]1958The Effects of Acute Hypoxia on the Osmotic Pressure of the Plasma. Quarterly Journal of Experimental Physiology 43: 197+, 1958. [With Donald H. Barron, Frederick C. Battaglia, and Giacomo Meschia]Studies on the Absorption of Vitamin B12 in Human Pregnancy with Especial Reference to the Effect of D-Sorbitol. American Journal of Obstetrics and Gynecology 76: 91+, 1958. [With Bacon F. Chow, Harry Prystowsky, and Vernon Wong]1959The Alveolar PCO2 and PO2 in Pregnant and Nonpregnant Women at Altitude. Proceedings of the Society for Clinical Investigation 38: 1010+, 1959. [With Donald Barron, William Huckabee, Giacomo Meschia, James Metcalfe, and Harry Prystowsky]A Comparison of the Oxygen Dissociation Curves of the Bloods of Maternal and Fetal Goats at Various pHs. Quarterly Journal of Experimental Physiology 44: 215–21, July 1959. [With Donald Barron, Giacomo Meschia, Harry Prystowsky, and A. Stark Wolkoff]Fetal Blood Studies. XII. On the Relationship Between the Position of the Oxygen Dissociation Curve of Human Fetal Blood and Adult Fetal Hemoglobin. American Journal of Obstetrics and Gynecology 77: 585+, 1959. [With Paul D. Bruns, Julian Cotter, and Harry Prystowsky]Fetal Blood Studies. XIV. A Comparative Study of the Oxygen Dissociation Curve of Nonpregnant, Pregnant and Fetal Human Blood. American Journal of Obstetrics and Gynecology 78: 489–93, September 1959. [With Paul D. Bruns and Harry Prystowsky]Fetal Blood Studies. XVI. On the Changes in Total Osmotic Pressure and Sodium and Potassium Concentration of Amniotic Fluid During the Course of Human Gestation. Surgery, Gynecology and Obstetrics 109: 509–12, October 1959. [With Frederick Battaglia, Paul D. Bruns, Harry Prystowsky, and Clayton Smisson]Further Observations on the Metabolism of Vitamin B12 in Human Pregnancy. American Journal of Obstetrics and Gynecology 77: 1+, 1959. [With Bacon F. Chow, Harry Prystowsky, Bruno Ranke, and Elma Ranke]The Oxygen Dissociation Curves of the Bloods of Adult and Fetal Llamas. Federation Proceedings 18, 1959. [With Donald Barron, William Huckabee, Giacomo Meschia, James Metcalfe, and Harry Prystowsky] [End Page 90]Transfer of Oxygen Across the Sheep Placenta at High Altitude. Federation Proceedings 18, 1959. [With Donald Barron, William Huckabee, Giacomo Meschia, and Harry Prystowsky]Uterine Blood Flow and Metabolism in Pregnant Sheep at High Altitude. Federation Proceedings 18, 1959. [With Donald Barron, William Huckabee, Giacomo Meschia, James Metcalfe, and Harry Prystowsky]Uterine Blood Flow and Metabolism in Unanesthetized Pregnant Sheep. Federation Proceedings 18, 1959. [With Donald Barron, William Huckabee, Giacomo... (shrink)

A publication by Professor Margenau is always of interest to persons concerned with philosophy of science. This is especially true, however, of his recently published book, The Nature of Physical Reality; for this book, dealing with basic epistemological problems arising from the development of modern quantum mechanics, is the most comprehensive and most systematic formulation of its author's philosophical position and is at the same time conceived as a “challenge” to “uncritical realism, unadorned operationalism, and radical empiricism”—to points of view, (...) that is, which Professor Margenau regards as “outmoded and in disharmony with the successful phases of contemporary physics”. (shrink)

Philosophy of science and, more specifically, philosophy of quantum physics can be but special fields of a general philosophy of knowledge; and the problems arising in these fields can be evaluated properly only when they are seen under the perspective of the whole range of human knowledge. This paper deals with problems of quantum physics and, in particular, with the problem of scientific objects in quantum physics from the epistemological point of view previously defined in the author's books, A Philosophy (...) of Science and The Basis and Structure of Knowledge. The argument of the paper, however, has not been stated before in the direct and concise manner here attempted and may therefore contain elements of novelty even for those readers who are familiar with the books just mentioned. (shrink)

Historians generally see ideas as the product of circumstances, looking beyond the idea to the external factor which influenced its acceptance. Behind an idea there are acknowledged or, more commonly, unacknowledged clusters of assumptions shared by a social group. Although these clusters influence thoughts, they cannot be traced as direct causal agents. In the connection between situations and ideas, how the situation is perceived is more important than what is objectively true. Rough causal laws can be outlined by correlating types (...) of social conditions with types of states of mind. Sets of ideas point beyond themselves to the background against which they were framed. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 97 supposed by actual idealism is above all moral and involves what Gentile describes as an aspect of divinity or infinity,as well as a concrete, historical aspect. The following chapter treats of the philosophy of "actual" idealism and compares the views of Kant and Gentile on relations between moral conscience and freedom. According to Yalentini, Gentile's idealism is essentially an ethical view. This chapter concludes with noting (...) that Gentile 's solution to the problem of historical knowledge differs profoundly from that of Hegel and Croce. For "reason" is not, for Gentile, a particular interpretation of historical process, but is rather the "reason" of consciousness in activity. In Chapter In, Valentini discusses Gentile's views on art and religion. The section on art concludes with a comparison between Gentile on feeling and Kant on the transcendental unity of apperception. Whereas art is supposed to be one abstract moment of spirit, religion is the other abstract moment. Valentini suggests that Gentile and Feuerbach hold similar religious views on the attributes of divinity, which are nothing other than the loftiest qualities which man feels to possess in his essence. The history of religion is then the history of the progressive humanization of God. Gentile's religion represents a sort of modem Catholicism in that it understands revelation as a fact of conscience, church as a historical institution, dogma as having a negative character and God as a member of the dialogue between God and man. Moreover, Gentile's Catholicism has a national character; it is the religion of the Italian people. Chapter Iv treats of the relations between individual and state. For, according to Gentile, an individual is inconceivableapart from the social relations which lie within him. Here Valentini distinguishes in detail the differences and similarities between the views of Hegel and Gentile on the relations between state and individual. The differences between the views of these two philosophers are due to the differences between their methods. The method of Hegel is empirical and historical, and examines the state (which remains historical) from an external point of view. According to an idealistic method, however, thought is not to be the spectator of a process, but in every instance, an actor, and philosophizing does not result from an analysis of historical reality, but from the negation of this reality in the name of an ideal, which philosophy is to draw from it (reality). The Appendix includes a critical evaluation of the theory of the dialectic. Here Valentini hopes to distinguish between the imaginary and the real or historical applications of the dialectic. He begins his evaluation by asking: Does the doctrine of the dialectic, like the philosophy of idealism, possess negative connotations, which cannot be separated from it? Valentini suggests that in order to answer this question, we must determine the extent to which the dialectical scheme is constitutive of every concept or truth in general. For this is the way in which Hegel intended that the dialectic be understood and evaluated. Some views in Hegel's philosophy of nature are then criticized according to empirical criteria. In conclusion, Valentini attempts to answer both "internal" and "external" criticisms of Marx's view of the dialectic, and shows that there are problems involved in its application, which still have to be resolved. Mv~ M. MILBURN 9 ~an Jos~ ~ate College Husserl und Kant: eine Untersuchung ~ber Husserls Verh~iltni~ zu Kant und zum Neubantianismus. By Iso Kern. (The Hague : Martinus Nijhoff, 1964.Pp. xxiii q- 448.) This is a very important book. In fact, it is indispensable for a study of Husserl and is, at the same time, almost as valuable for a study of Kant, for it deals with the kind of searching questions that must be asked when one deals with transcendental idealism in any one of its forms. But two reasons in particular, make this book significant. One is the fact that Iso Kern was able to make extensive use of hitherto unpublished materials (manuscripts, lecture notes, letters, etc.), available only in the Husserl Archives and here quoted for the first time--and 98 HISTORY OF PHILOSOPHY quoted in great numbers. The other is Kern's philosophical competence... (shrink)

A short time ago, D. D. Lee wrote in Philosophy of Science: “Grammar contains in crystallized form the accumulated and accumulating experience, the Weltanschauung of a people.“ He thus called our attention once more to a theme which was much discussed during the 19th century but which has been in disrepute for some time in philosophical circles. It is a theme, however, which is not without merit. More than seven years of intensive study of primitive languages have convinced me that (...) the work started by Wilhelm von Humboldt deserves serious consideration even at present, and from the ethnological as well as from the philosophical point of view. (shrink)